eTMF | Electronic Trial Master File

A trial master file that is always inspection-ready.

EClinCloud eTMF manages trial documents across their full lifecycle — collection, storage, retrieval, sharing, and tracking — in line with GCP and FDA 21 CFR Part 11.

SponsorsCROsSite Staff / ResearchersQA / Auditors & Inspectors
ECC eTMF · live workspaceLIVE
DIA reference modelTMF readiness
2,418Documents
96%Complete
18Needs review
Uploaded48
Verified record
Classified42
Verified record
Filed38
Verified record
Trial management742 files
Central trial documents1,204 files
Site management472 files
12 documents classified automatically
01

Filed right the first time

AI reads document content, study, site, and TMF Index context to suggest classification and filing location — fewer misfiles and less manual judgment.

02

Quality checked upstream

AI QC flags duplicates, blank pages, watermarks, and blurred content at upload, shifting quality control forward and cutting rework.

03

Ready for inspection

Managers see TMF completeness, timeliness, and quality in real time, and inspectors get a straightforward path through audit and review.

How it works

01
Stage 1

Capture at the site

Scan documents with the ECC ONE mobile app — automatic recognition, image correction, and quality checks lower the cost of on-site collection.

02
Stage 2

Classify with AI

AI reads content, study, site, document type, and TMF Index context to suggest the right category and filing location.

03
Stage 3

QC before filing

Duplicates, blank pages, watermarks, and blurred content are caught automatically before they enter the TMF.

04
Stage 4

Confirm and file

After human confirmation, documents are filed by site, participant, and visit — viewable online and shareable across the team.

05
Stage 5

Monitor and inspect

Completeness, timeliness, and quality status stay visible in real time, with search and tracking that stand up to audits.

Core capabilities

Document capture

  • Smart scanning with the ECC ONE mobile app
  • Automatic image recognition and correction
  • Assisted quality checks before upload

Filing & retrieval

  • TMF Index-based classification and filing
  • Organized by site, participant, and visit
  • Centralized upload with online viewing, search, and sharing

Compliance & quality

  • Aligned with GCP and FDA 21 CFR Part 11
  • Real-time visibility into completeness, timeliness, and quality
  • Accuracy, integrity, security, and traceability by design
  • A straightforward experience for audits and inspections

Migration & advisory

  • TMF data migration services
  • TMF management framework design
  • Global TMF compliance consulting
  • One-on-one role-based training

AI where it helps

Smart mobile scanning

Documents scanned via the ECC ONE app are auto-recognized, corrected, and quality-checked — lower collection cost at the site, higher quality at upload.

AI classification & filing

AI uses content, study, site, document type, and TMF Index signals to suggest the right category and filing location, cutting misfiles and manual triage.

AI-powered QC

Duplicates, blanks, watermarks, and blur are flagged automatically, moving quality control upstream and reducing missing or non-conforming files.

LinBot AI assistant

A role-aware assistant that answers system, workflow, and how-to questions around the clock, in multiple languages.

Connected by design

⇄ CTMS
Native connectivity with CTMS for efficient filing.
← ECC ONE
Mobile scanning sends site documents straight into the TMF.
→ Auditors
A convenient, controlled path for regulators and inspectors.
← eLearning
Onboarding training delivered online with a traceable record.

Services & implementation

Study build, migration, training and managed operations come from the same team — implementing and supporting eTMF never needs another vendor. See services →

Frequently asked

Our legacy TMF is scattered across drives and cloud folders — can you migrate it?
Yes. TMF migration services cover reviewing, converting, and migrating historical documents into eTMF, with proven cases connecting legacy archives seamlessly to active studies.
Which compliance standards does the system meet?
The system aligns with GCP and follows FDA 21 CFR Part 11, safeguarding accuracy, integrity, security, and traceability — and global TMF compliance consulting is available on top.
What if AI classifies a document incorrectly?
AI suggests the category and filing location to reduce manual triage and misfiles; filing is confirmed by a person, and AI QC intercepts duplicates, blanks, and blurred files before they land in the TMF.
What about deployment and data residency?
Regional deployment options are available; the specific architecture and data residency arrangement are confirmed with your team during evaluation.

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See eTMF on your own study.

Bring a protocol or a question — we'll shape the walkthrough around it.

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